Background: The common treatment for pediatric cataracts is to replace the cloudy lens with an artificial one. However, patients may suffer complications (severe lens proliferation into the visual axis and abnormal high intraocular pressure; SLPVA and AHIP) within 1 year after surgery and factors causing these complications are unknown.
Methods: Apriori algorithm is employed to find association rules related to complications. We use random forest (RF) and Naïve Bayesian (NB) to predict the complications with datasets preprocessed by SMOTE (synthetic minority oversampling technique). Genetic feature selection is exploited to find real features related to complications.
Results: Average classification accuracies in three binary classification problems are over 75%. Second, the relationship between the classification performance and the number of random forest tree is studied. Results show except for gender and age at surgery (AS); other attributes are related to complications. Except for the secondary IOL placement, operation mode, AS and area of cataracts; other attributes are related to SLPVA. Except for the gender, operation mode, and laterality; other attributes are related to the AHIP. Next, the association rules related to the complications are mined out. Then additional 50 data were used to test the performance of RF and NB, both of then obtained the accuracies of over 65% for three classification problems. Finally, we developed a webserver to assist doctors.
Conclusions: The postoperative complications of pediatric cataracts patients can be predicted. Then the factors related to the complications are found. Finally, the association rules that is about the complications can provide reference to doctors.
Keywords: Association rules mining; Genetic feature selection; Medical decision making system; Naïve Bayesian; Random forest.