High Prevalence of Bedaquiline Resistance in Treatment-Naive Tuberculosis Patients and Verapamil Effectiveness

Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02530-18. doi: 10.1128/AAC.02530-18. Print 2019 Mar.

Abstract

In the regions where bedaquiline (BDQ) is introduced into the regimen, analysis of MIC and screening for preexisting resistance mutations could be crucial. The high prevalence of isolates with high BDQ MICs without prior exposure to BDQ was worrisome. It was also concluded that efflux pumps play a pivotal role in intrinsic BDQ resistance; therefore, the potential of verapamil as an adjunctive therapy to combat BDQ resistance should be investigated.

Keywords: MIC; WGS; bedaquiline; efflux pumps; verapamil.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Diarylquinolines / therapeutic use*
  • Drug Resistance, Bacterial / genetics*
  • Humans
  • Iran
  • Membrane Transport Proteins / genetics
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification
  • Retrospective Studies
  • Tuberculosis, Pulmonary / drug therapy*
  • Verapamil / therapeutic use*

Substances

  • Antitubercular Agents
  • Diarylquinolines
  • Membrane Transport Proteins
  • bedaquiline
  • Verapamil