The lysosome as a cellular centre for signalling, metabolism and quality control

Nat Cell Biol. 2019 Feb;21(2):133-142. doi: 10.1038/s41556-018-0244-7. Epub 2019 Jan 2.


Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth, division and differentiation. Lysosomes interface physically and functionally with other organelles, and the master regulator mechanistic target of rapamycin complex 1 kinase is activated on lysosomes in response to nutrient and growth factor inputs. Lysosomes also enable autophagy, a 'self-eating' process essential for quality control and stress adaptation. Faulty execution of lysosomal growth and catabolic programmes drives cancer, neurodegeneration and age-related diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy
  • Homeostasis
  • Humans
  • Intracellular Space / metabolism*
  • Lysosomes / metabolism*
  • Metabolic Networks and Pathways*
  • Models, Biological
  • Quality Control
  • Signal Transduction*