mTOR as a central hub of nutrient signalling and cell growth

Nat Cell Biol. 2019 Jan;21(1):63-71. doi: 10.1038/s41556-018-0205-1. Epub 2019 Jan 2.


The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth regulator connecting cellular metabolism and growth with a wide range of environmental inputs as part of mTOR complex 1 (mTORC1) and mTORC2. In this Review, we introduce the landmark discoveries in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations of key components of the mTORC signalling network with an emphasis on amino acid sensing, and discuss the perspectives of mTORC inhibitors in therapeutic applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / physiology
  • Animals
  • Cell Cycle / physiology
  • Cell Proliferation / physiology*
  • Humans
  • Models, Biological
  • Nutrients / physiology*
  • Signal Transduction / physiology*
  • TOR Serine-Threonine Kinases / metabolism*


  • Amino Acids
  • TOR Serine-Threonine Kinases