Stem cell dynamics, migration and plasticity during wound healing

Nat Cell Biol. 2019 Jan;21(1):18-24. doi: 10.1038/s41556-018-0237-6. Epub 2019 Jan 2.


Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem cells recruited from various skin regions together with other cell types, including fibroblasts and immune cells, is required to ensure efficient and harmonious wound healing. A complex crosstalk ensures the activation, migration and plasticity of these cells during tissue repair.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology*
  • Cell Plasticity / physiology*
  • Cell Proliferation / physiology
  • Endothelial Cells / cytology
  • Endothelial Cells / physiology
  • Fibroblasts / cytology
  • Fibroblasts / physiology
  • Humans
  • Keratinocytes / cytology
  • Keratinocytes / physiology
  • Stem Cells / cytology
  • Stem Cells / physiology*
  • Wound Healing / physiology*