Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors.
Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas.
Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas.
Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.
Keywords: 5-Aminolevulinic acid; Fluorescence-guided surgery; Meningioma; Protoporphyrin IX; Quantitative fluorescence; Spectroscopy.