Regulatory landscape of the Hox transcriptome

Int J Dev Biol. 2018;62(11-12):693-704. doi: 10.1387/ijdb.180270em.


Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Embryonic Development / physiology
  • Gene Expression Regulation, Developmental*
  • Genes, Homeobox / genetics*
  • MicroRNAs / genetics
  • RNA, Long Noncoding / genetics
  • Transcriptome*


  • MicroRNAs
  • RNA, Long Noncoding