Vascular Regeneration With New Sources of Endothelial Cells

Circ Res. 2019 Jan 4;124(1):29-31. doi: 10.1161/CIRCRESAHA.118.314195.


Two new sources of ECs were generated from human induced pluripotent stem cells (hiPSCs), and by direct reprogramming of somatic cells without undergoing the stages of stem or progenitor cell. These two types of ECs will advance our understanding of EC biology and can become a novel therapeutic option for treating ischemic cardiovascular diseases.

Keywords: cardiovascular diseases; cellular reprogramming; endothelial cells; human pluripotent; regeneration; stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / surgery*
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Reprogramming Techniques*
  • Cellular Reprogramming*
  • Endothelial Progenitor Cells / metabolism
  • Endothelial Progenitor Cells / transplantation*
  • Genotype
  • Humans
  • Induced Pluripotent Stem Cells / metabolism
  • Induced Pluripotent Stem Cells / transplantation*
  • Neovascularization, Physiologic*
  • Phenotype
  • Regeneration*
  • Regenerative Medicine / methods*


  • Biomarkers