Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche Populations

J E Le Belle; H I Kornblum

doi:10.1016/j.neuron.2018.12.017

Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche Populations

Neuron. 2019 Jan 2;101(1):1-2. doi: 10.1016/j.neuron.2018.12.017.

Authors

J E Le Belle¹, H I Kornblum²

Affiliations

¹ Semel Institute for Neuroscience and Behavior and Departments of Psychiatry, University of California Los Angeles, Los Angeles, California, 90095 United States. Electronic address: jlebelle@mednet.ucla.edu.
² Semel Institute for Neuroscience and Behavior and Departments of Psychiatry, University of California Los Angeles, Los Angeles, California, 90095 United States; Pharmacology and Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095 United States.

PMID: 30605653
DOI: 10.1016/j.neuron.2018.12.017

Abstract

Microenvironment cues and cell-to-cell interactions balance stem cell quiescence with proliferation and direct neurogenesis in the adult hippocampal niche. Tang et al. report that hippocampal stem cells release feedback signals that regulate the dendritic complexity and activity of newborn neurons.

Publication types

Comment

MeSH terms

Adult
Hippocampus
Humans
Infant, Newborn
Neural Stem Cells*
Neurogenesis
Neurons
Stem Cell Niche*

Grants and funding

P50 HD103557/HD/NICHD NIH HHS/United States