The NeuroDev Study: Phenotypic and Genetic Characterization of Neurodevelopmental Disorders in Kenya and South Africa

Victoria de Menil; Michelle Hoogenhout; Patricia Kipkemoi; Dorcas Kamuya; Emma Eastman; Alice Galvin; Katini Mwangasha; Jantina de Vries; Symon M Kariuki; Serini Murugasen; Paul Mwangi; Ilina Singh; Dan J Stein; Amina Abubakar; Charles R Newton; Kirsten A Donald; Elise Robinson

doi:10.1016/j.neuron.2018.12.016

The NeuroDev Study: Phenotypic and Genetic Characterization of Neurodevelopmental Disorders in Kenya and South Africa

Neuron. 2019 Jan 2;101(1):15-19. doi: 10.1016/j.neuron.2018.12.016.

Authors

Victoria de Menil¹, Michelle Hoogenhout², Patricia Kipkemoi³, Dorcas Kamuya⁴, Emma Eastman², Alice Galvin⁵, Katini Mwangasha³, Jantina de Vries⁶, Symon M Kariuki⁷, Serini Murugasen², Paul Mwangi³, Ilina Singh⁸, Dan J Stein⁹, Amina Abubakar¹⁰, Charles R Newton⁷, Kirsten A Donald¹¹, Elise Robinson¹²

Affiliations

¹ Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02142, USA.
² Department of Paediatrics & Child Health, 4(th) Floor ICH Building, Red Cross War Memorial Children's Hospital and University of Cape Town, Rondebosch, South Africa.
³ Neurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Collaborative Research Programme, PO Box 230-80108, Kilifi, Kenya.
⁴ Department of Health Systems and Research Ethics, KEMRI-Wellcome Trust Collaborative Research Programme, Kilifi, Kenya.
⁵ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
⁶ Department of Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.
⁷ Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK; Neurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Collaborative Research Programme, PO Box 230-80108, Kilifi, Kenya.
⁸ Department of Psychiatry and Wellcome Centre for Ethics and Humanities, University of Oxford, Oxford, UK.
⁹ Department of Psychiatry & Mental Health, and MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, J-Block, Groote Schuur Hospital, Observatory, Cape Town, South Africa.
¹⁰ Neurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Collaborative Research Programme, PO Box 230-80108, Kilifi, Kenya. Electronic address: aabubakar@kemri-wellcome.org.
¹¹ Department of Paediatrics & Child Health, 4(th) Floor ICH Building, Red Cross War Memorial Children's Hospital and University of Cape Town, Rondebosch, South Africa. Electronic address: kirsty.donald@uct.ac.za.
¹² Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Richard B. Simches Building, 6(th) Floor, 185 Cambridge Street, Boston, MA 02114, USA. Electronic address: erob@broadinstitute.org.

Abstract

The NeuroDev study will deeply phenotype cognition, behavior, dysmorphias, and neuromedical traits on an expected cohort of 5,600 Africans (1,800 child cases, 1,800 child controls, and 1,900 parents) and will collect whole blood for exome sequencing and biobanking.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adolescent
Child
Child, Preschool
Cohort Studies
Female
Genetic Testing / methods*
Humans
Kenya / epidemiology
Male
Neurodevelopmental Disorders / diagnosis
Neurodevelopmental Disorders / epidemiology*
Neurodevelopmental Disorders / genetics*
Phenotype*
South Africa / epidemiology

Abstract

Publication types

MeSH terms

Grants and funding