Sodium Is Detected by the OVLT to Regulate Sympathetic Tone

Neuron. 2019 Jan 2;101(1):3-5. doi: 10.1016/j.neuron.2018.12.015.

Abstract

Hypernatremia is known to elicit a rise in sympathetic tone and blood pressure. In this issue of Neuron, Nomura et al. (2018) now show that this is mediated via the organum vasculosum laminae terminalis (OVLT). Na+ activates OVLT neurons via a paracrine mechanism involving sodium channel Nax expressed by astrocytes and the ependyma.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Astrocytes
  • Blood Pressure
  • Body Fluids*
  • Organum Vasculosum*
  • Sodium

Substances

  • Sodium