Derivation of iPSC lines from two patients with familial Alzheimer's disease from India

Stem Cell Res. 2019 Jan;34:101370. doi: 10.1016/j.scr.2018.101370. Epub 2018 Dec 19.

Abstract

The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / pathology*
  • Base Sequence
  • Cell Line
  • Female
  • Humans
  • India
  • Induced Pluripotent Stem Cells / pathology*
  • Middle Aged