Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar;35(3):186-198.
doi: 10.1016/j.tig.2018.12.003. Epub 2018 Dec 31.

Translation of Small Open Reading Frames: Roles in Regulation and Evolutionary Innovation

Affiliations
Review

Translation of Small Open Reading Frames: Roles in Regulation and Evolutionary Innovation

Jorge Ruiz-Orera et al. Trends Genet. .

Abstract

The translatome can be defined as the sum of the RNA sequences that are translated into proteins in the cell by the ribosomal machinery. Until recently, it was generally assumed that the translatome was essentially restricted to evolutionary conserved proteins encoded by the set of annotated protein-coding genes. However, it has become increasingly clear that it also includes small regulatory open reading frames (ORFs), functional micropeptides, de novo proteins, and the pervasive translation of likely nonfunctional proteins. Many of these ORFs have been discovered thanks to the development of ribosome profiling, a technique to sequence ribosome-protected RNA fragments. To fully capture the diversity of translated ORFs, we propose a comprehensive classification that includes the new types of translated ORFs in addition to standard proteins.

Keywords: de novo protein; micropeptide; open reading frame; ribosome profiling; translatome.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback