Polydopamine doped reduced graphene oxide/mesoporous silica nanosheets for chemo-photothermal and enhanced photothermal therapy

Rong Liu; Huicong Zhang; Fangrong Zhang; Xuandong Wang; Xiaolong Liu; Yun Zhang

doi:10.1016/j.msec.2018.10.093

Polydopamine doped reduced graphene oxide/mesoporous silica nanosheets for chemo-photothermal and enhanced photothermal therapy

Mater Sci Eng C Mater Biol Appl. 2019 Mar:96:138-145. doi: 10.1016/j.msec.2018.10.093. Epub 2018 Nov 1.

Authors

Rong Liu¹, Huicong Zhang¹, Fangrong Zhang¹, Xuandong Wang¹, Xiaolong Liu², Yun Zhang³

Affiliations

¹ Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361021, People's Republic of China; Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China.
² Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361021, People's Republic of China; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People's Republic of China. Electronic address: xiaoloong.liu@gmail.com.
³ Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361021, People's Republic of China; Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People's Republic of China. Electronic address: zhangy@fjirsm.ac.cn.

PMID: 30606519
DOI: 10.1016/j.msec.2018.10.093

Abstract

The nanoplatform of synergistic chemo-photothermal therapy has superior advantages on antitumor. It is urgently needed to explore novel nanocarrier for improving photothermal performance in drug delivery process. Herein, we synthesized polydopamine doped mesoporous silica-coated reduced graphene oxide (rGO/MSN/PDA) by simply adding dopamine hydrochloride into the oil-water biphasic reaction system as a multifunctional drug carrier for anticancer treatment, which combines chemotherapy and photothermal therapy. The rGO/MSN/PDA showed nearly twice the photothermal conversion efficiency of mesoporous silica-coated graphene oxide (GO/MSN) due to the reduction of GO and doping with PDA. In addition, the rGO/MSN/PDA showed pH-response DOX release abilities, which means higher release of DOX in tumor cells. The cell experiments in vitro proved that rGO/MSN/PDA with better biocompatibility compare to GO/MSN might offer a promising tool for improving the therapeutic effects of hepatocellular carcinoma cells through synergistic chemo-photothermal therapy.

Keywords: Chemo-photothermal therapy; Mesoporous silica; Polydopamine; Reduced graphene oxide.

MeSH terms

Cell Line, Tumor
Doxorubicin* / chemistry
Doxorubicin* / pharmacokinetics
Doxorubicin* / pharmacology
Drug Carriers* / chemistry
Drug Carriers* / pharmacokinetics
Drug Carriers* / pharmacology
Graphite* / chemistry
Graphite* / pharmacokinetics
Graphite* / pharmacology
Humans
Hyperthermia, Induced*
Indoles* / chemistry
Indoles* / pharmacokinetics
Indoles* / pharmacology
Neoplasms / metabolism
Neoplasms / pathology
Neoplasms / therapy*
Phototherapy*
Polymers* / chemistry
Polymers* / pharmacokinetics
Polymers* / pharmacology
Silicon Dioxide* / chemistry
Silicon Dioxide* / pharmacokinetics
Silicon Dioxide* / pharmacology

Substances

Drug Carriers
Indoles
Polymers
graphene oxide
polydopamine
Silicon Dioxide
Graphite
Doxorubicin