Progress in the understanding of polycystic kidney disease

Nat Rev Nephrol. 2019 Feb;15(2):70-72. doi: 10.1038/s41581-018-0108-1.

Abstract

The function of polycystin proteins and the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) are not well understood. Studies published in 2018 made important contributions to the understanding of genetic mechanisms, the structure of the polycystin complex and the roles of G-protein signalling and the immune system in ADPKD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism
  • GTP-Binding Proteins / metabolism
  • Genetic Markers
  • Humans
  • Mutation
  • Polycystic Kidney, Autosomal Dominant* / genetics
  • Polycystic Kidney, Autosomal Dominant* / immunology
  • Polycystic Kidney, Autosomal Dominant* / metabolism
  • Signal Transduction
  • TRPP Cation Channels / genetics
  • TRPP Cation Channels / metabolism

Substances

  • Biomarkers
  • GTP-Binding Proteins
  • Genetic Markers
  • TRPP Cation Channels