Neonatal Lethality and Inflammatory Phenotype of the New Transgenic Mice with Overexpression of Human Interleukin-6 in Myeloid Cells

Dokl Biochem Biophys. 2018 Nov;483(1):344-347. doi: 10.1134/S1607672918060157. Epub 2019 Jan 3.


To model human interleukin-6 (hIL-6) associated diseases, unique mice with transgenic overexpression of human IL-6 and reporter fluorescent protein EGFP in cells of macrophage-monocyte lineage were generated using loxP-Cre system. High level of hIL-6 production by macrophages and monocytes, as confirmed in vitro in primary culture of bone marrow-derived macrophages, in vivo resulted in early postnatal death in vivo, presumably, due to the effect of overexpression of hIL-6 on hematopoiesis.

MeSH terms

  • Animals
  • Green Fluorescent Proteins / biosynthesis
  • Green Fluorescent Proteins / genetics
  • Hematopoiesis*
  • Humans
  • Interleukin-6* / biosynthesis
  • Interleukin-6* / genetics
  • Macrophages / cytology
  • Macrophages / metabolism*
  • Mice
  • Mice, Transgenic
  • Monocytes / cytology
  • Monocytes / metabolism*


  • IL6 protein, human
  • Interleukin-6
  • enhanced green fluorescent protein
  • Green Fluorescent Proteins