Sufficient Cause Interaction for Time-to-event Outcomes

Epidemiology. 2019 Mar;30(2):189-196. doi: 10.1097/EDE.0000000000000958.

Abstract

Methods to assess sufficient cause interactions are well developed for binary outcomes. We extend these methods to handle time-to-event outcomes, which occur frequently in medicine and epidemiology. Based on theory for marginal structural models in continuous time, we show how to assess sufficient cause interaction nonparametrically, allowing for censoring and competing risks. We apply the method to study interaction between intensive blood pressure therapy and statin treatment on all-cause mortality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Data Interpretation, Statistical
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hypertension / drug therapy*
  • Hypertension / epidemiology*
  • Middle Aged
  • Models, Statistical
  • Probability
  • Proportional Hazards Models
  • Survival Analysis
  • Time Factors

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors