The Managment of cervical spine abnormalities in children with spondyloepiphyseal dysplasia congenita: Observational study

Medicine (Baltimore). 2019 Jan;98(1):e13780. doi: 10.1097/MD.0000000000013780.


Spondyloepiphyseal dysplasia congenita (SEDC) is an autosomal dominant disorder, characterized by disproportionate dwarfism with short spine, short neck associated with variable degrees of coxa vara. Cervical cord compression is the most hazardous skeletal deformity in patients with SEDC which requires special attention and management.Ten patients with the clinical and the radiographic phenotypes of spondyloepiphyseal dysplasia congenita have been recognized and the genotype was compatible with single base substitutions, deletions or duplication of part of the COL2A1 gene (6 patients out of ten have been sequenced). Cervical spine radiographs showed apparent atlantoaxial instability in correlation with odontoid hypoplasia or os-odontoideum.Instability of 8 mm or more and or the presence of symptoms of myelopathy were the main indications for surgery. Posterior cervical fusion from the occiput or C1-3, decompression of C1-2 and application of autorib transfer followed by halo vest immobilization have been applied accordingly.Orthopedic management of children with spondyloepiphyseal dysplasia congenita (SEDC) should begin with the cervical spine to avoid serious neurological deficits and or mortality.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Axis, Cervical Vertebra / surgery
  • Cervical Vertebrae / diagnostic imaging
  • Cervical Vertebrae / surgery*
  • Child
  • Child, Preschool
  • Collagen Type II / genetics
  • Decompression, Surgical / methods*
  • Female
  • Humans
  • Joint Instability / congenital
  • Joint Instability / surgery
  • Male
  • Osteochondrodysplasias / complications
  • Osteochondrodysplasias / congenital*
  • Osteochondrodysplasias / genetics
  • Osteochondrodysplasias / surgery
  • Spinal Cord Compression / congenital
  • Spinal Cord Compression / surgery*
  • Spinal Cord Diseases / congenital
  • Spinal Cord Diseases / surgery
  • Spinal Diseases / congenital
  • Spinal Diseases / surgery
  • Spinal Fusion / methods*
  • Treatment Outcome


  • COL2A1 protein, human
  • Collagen Type II

Supplementary concepts

  • Spondyloepiphyseal dysplasia, congenita