Review of primary and secondary erythromelalgia

Clin Exp Dermatol. 2019 Jul;44(5):477-482. doi: 10.1111/ced.13891. Epub 2019 Jan 4.

Abstract

Erythromelalgia is a condition characterized by episodic pain, erythema and temperature of the extremities, which is relieved by cooling and aggravated by warming. It is useful to review this topic in light of recent discoveries of the genetic mutations that now define primary erythromelalgia, as opposed to secondary erythromelalgia, which is often associated with underlying medical disorders.

Publication types

  • Review

MeSH terms

  • Capsaicin / therapeutic use
  • Erythromelalgia / complications
  • Erythromelalgia / diagnosis*
  • Erythromelalgia / genetics
  • Erythromelalgia / therapy
  • Humans
  • Mass Screening
  • Mexiletine / therapeutic use
  • Myeloproliferative Disorders / complications
  • Myeloproliferative Disorders / diagnosis
  • NAV1.7 Voltage-Gated Sodium Channel / genetics
  • Ranolazine / therapeutic use
  • Sensory System Agents / therapeutic use
  • Sodium Channel Blockers / therapeutic use
  • Sympathectomy

Substances

  • NAV1.7 Voltage-Gated Sodium Channel
  • SCN9A protein, human
  • Sensory System Agents
  • Sodium Channel Blockers
  • Mexiletine
  • Ranolazine
  • Capsaicin