The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease

Mol Cell. 2019 Jan 3;73(1):5-6. doi: 10.1016/j.molcel.2018.12.011.


Parkinson's disease (PD) is characterized by protein aggregates of α-synuclein in neurons. In a recent issue of Science, Kam et al. (2018) revealed a feedforward loop in which α-synuclein increases the levels of poly(adenosine 5'-diphosphate-ribose) (PAR) that in turn causes α-synuclein aggregates to be more toxic. This study advances our understanding of PD pathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Death
  • Humans
  • Neurons
  • Parkinson Disease*
  • Polymers
  • alpha-Synuclein*


  • Polymers
  • alpha-Synuclein