Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-associated lymphoproliferative disorders

Blood. 2019 Mar 14;133(11):1186-1190. doi: 10.1182/blood-2018-11-852442. Epub 2019 Jan 4.


Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 is associated with multicentric Castleman disease (MCD) and primary effusion lymphoma (PEL). In MCD, infected B cells, although polyclonal, express a monotypic immunoglobulin Mλ phenotype, probably through editing toward λ light chain in mature B cells. They are considered to originate from pre-germinal center (GC) naive B cells. Both viral and human interleukin-6 contribute to the plasmacytic differentiation of these cells, and viral replication can be observed in some infected cells. PEL cells are clonal B cells considered as GC/post-GC B cells. One can also hypothesize that they originate from the same infected naive B cells and that additional factors could be responsible for their peculiar phenotype.

Publication types

  • Review

MeSH terms

  • Herpesvirus 8, Human / pathogenicity*
  • Humans
  • Lymphoproliferative Disorders / etiology*
  • Lymphoproliferative Disorders / pathology
  • Prognosis
  • Sarcoma, Kaposi / complications*
  • Sarcoma, Kaposi / virology