Bacterial susceptibility in bloodstream infections: Results from China Antimicrobial Resistance Surveillance Trial (CARST) Program, 2015-2016

J Glob Antimicrob Resist. 2019 Jun:17:276-282. doi: 10.1016/j.jgar.2018.12.016. Epub 2019 Jan 3.

Abstract

Objectives: The aim of this study was to monitor the trends in antimicrobial resistance from the blood samples isolated from the Chinese mainland.

Methods: All clinical isolates were collected from 18 hospitals. The minimal inhibitory concentrations (MICs) were tested in a central laboratory using the agar dilution method recommended by the Clinical and Laboratory Standards Institute. The susceptibilities of isolates to antimicrobial agents were determined by using Clinical and Laboratory Standards Institute or European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2017 guidelines.

Results: A total of 1758 strains of various types with the sum≥30 were isolated from blood specimens in 2015-2016. The detection rates of extended-spectrum β-lactamases (ESBLs) among Escherichia coli were 55.6%, whereas those in Klebsiella pneumoniae were 22.4%. Carbapenems, moxalactam, tigecycline, and amikacin displayed desirable antibacterial activity against Enterobacteriaceae, but a significant increase in Klebsiella pneumoniae to carbapenems was noted. Nonfermenters were highly resistant to carbapenems, especially in Acinetobacter Baumannii isolates, >70％ of which were resistant. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) reached 36.1% and 90.4%, respectively. Staphylococcus aureus had 100% susceptibility to vancomycin. Enterococcus faecium isolates showed significantly higher resistant rates to most of the tested antimicrobial agents than Enterococcus faecalis isolates. While vancomycin-resistant Enterococcus (VRE) was 3.28%, the non-susceptible rate of linezolid to Enterococcus faecalis was 6.8%.

Conclusions: This study revealed the major bacterial pathogens' antibiotic susceptibility patterns involved with bloodstream infection in mainland China.

Keywords: Bloodstream infection; Minimum inhibitory concentration; Susceptibility.

MeSH terms

  • Acinetobacter baumannii / drug effects
  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / microbiology*
  • Bacterial Typing Techniques / methods
  • China
  • Drug Resistance, Bacterial / drug effects*
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / isolation & purification
  • Enterococcus faecium / drug effects
  • Enterococcus faecium / isolation & purification
  • Escherichia coli / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Negative Bacteria / isolation & purification
  • Gram-Positive Bacteria / drug effects
  • Gram-Positive Bacteria / isolation & purification
  • Humans
  • Klebsiella pneumoniae / isolation & purification
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Microbial Sensitivity Tests / methods*
  • Staphylococcus aureus / drug effects
  • Vancomycin-Resistant Enterococci / drug effects
  • Vancomycin-Resistant Enterococci / isolation & purification

Substances

  • Anti-Bacterial Agents