Abstract
Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) were effective in augmentation of killer cells generation from human peripheral blood mononuclear cells (PBMC) in response to recombinant human interleukin-2 (IL-2). Pretreatment of PBMC with combination of LPS and MDP resulted in most significant their proliferation stimulated by IL-2. Thus our results show the enhancement of PBMC sensitivity to IL-2 by action of LPS, MDP and most of all by their combination in vitro.
MeSH terms
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Acetylmuramyl-Alanyl-Isoglutamine / pharmacology*
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Cell Division / drug effects
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Cells, Cultured
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Escherichia coli*
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Female
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Humans
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Interleukin-2 / pharmacology*
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Killer Cells, Natural / cytology
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Killer Cells, Natural / drug effects
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Killer Cells, Natural / immunology
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Leukocytes, Mononuclear / cytology
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Leukocytes, Mononuclear / drug effects*
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Leukocytes, Mononuclear / immunology
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Lipopolysaccharides / pharmacology*
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Lymphocyte Activation / drug effects*
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Male
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Recombinant Proteins / pharmacology
Substances
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Interleukin-2
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Lipopolysaccharides
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Recombinant Proteins
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Acetylmuramyl-Alanyl-Isoglutamine