The biological functions of high-mobility group (HMG) proteins include regulation of DNA replication, transcription, recombination and repair. According to molecular weight, sequence alignment and DNA structural characteristics, HMG proteins are subdivided into three superfamilies (HMGA, HMGB and HMGN). Recently, HMGB family members (HMGB1, HMGB2, HMGB3, and HMGB4) found to interact with hepatitis B or C virus. Therefore, activation of relevant signaling molecules to regulate transcription of genes related to hepatocellular carcinoma as a mediator of inflammation promoting HCC progression has attracted considerable attentions. This article focuses on the clinical application of the expression of HMGB family members in the process of HCC progression.
核蛋白高迁移率族蛋白超家族（HMG）的生物学功能包括调节DNA复制、转录、重组和修复等。HMG蛋白超家族根据分子量大小、序列相似性和DNA结构特性分为HMGA、HMGB和HMGN家族。近来发现HMGB家族成员（HMGB1、HMGB2、HMGB3和HMGB4）与乙型或丙型肝炎病毒相互作用，活化相关信号分子，调控肝细胞性肝癌（HCC）相关基因转录，作为炎症介质促进HCC进展而倍受关注。现重点综述了HCC进展过程中HMGB家族成员表达的临床价值。.
Keywords: Carcinoma, hepatocellular; Diagnosis; Molecular target; Prognosis; Subgroup of high mobility group box family.