The article presents analysis of main indices of lipid specter and level of glucose in blood of aborigines and Caucasians during winter and spring seasons. The study covered 184 male youths aged from 17 to 21 years (18.2±0.8) studying in the North-Eastern state university (Magadan). The study was implemented using portable biochemical express-analyzer CardioChek PA (USA) by means of capillary blood sampling taking in morning hours on an empty stomach from finger 10-12 hours later after last food intake. The purpose of study was to compare characteristics of season variations of main characteristics of lipid and carbohydrate metabolism in aborigines and natives of the North-East of Russia from among Caucasians in102 generation (autochthonic population). The results of biochemical analyses, obtained in various seasons, demonstrated that average values of all analyzed characteristics of lipid profile approximated to lower limit of normal variation of indication. By all appearance, this is related to substrate energy inadequacy and with lipid alimentary deficiency in particular observed in examined students during analysis of their dietary intake where percentage of fat was in the limits of 65-70 g per day. The analysis of carbohydrate metabolism in male youths of different ethnic groups established that level of glucose was at the higher limit of reference intervals of normoglycemia. At that, in the group of aborigines season reorientation in analyzed values of metabolic profile were observed related to decreasing of level of glucose in blood while in group of Caucasians similar tendency was not observed. Apparently, the given season dynamics of metabolic processes in young aborigines indicates to efficiency of their evolutionary fixed mechanisms of adaptation developed in conditions of the North-East of Russia.