Microglia: Picky Brain Eaters

Ambra Villani; Francesca Peri

doi:10.1016/j.devcel.2018.12.013

Microglia: Picky Brain Eaters

Dev Cell. 2019 Jan 7;48(1):3-4. doi: 10.1016/j.devcel.2018.12.013.

Authors

Ambra Villani¹, Francesca Peri²

Affiliations

¹ Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
² Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. Electronic address: francesca.peri@uzh.ch.

PMID: 30620901
DOI: 10.1016/j.devcel.2018.12.013

Abstract

Many aspects of brain development, function, and repair depend on the interaction of neurons with brain immune cells, the microglia. By combining CLEM and SPIM microscopy, a recent study has challenged the current view that microglia can "eat" entire synapses, highlighting the incredible complexity of neuronal-microglial interactions in vivo.

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MeSH terms

Brain
Microglia*
Neurons
Pseudopodia*
Synapses