Azathioprine as a single drug or in combination with steroids in the treatment of myasthenia gravis

J Neurol. 1988 Nov;235(8):449-53. doi: 10.1007/BF00314245.


Azathioprine (Aza) has been used alone or in combination with steroids for two groups of myasthenic patients. Positive responses were noted in 75% of patients on Aza alone and in 70% receiving the combined regimen. The clinical course of the two groups differed in terms of respiratory crisis and need for plasma exchange. With an appropriate Aza administration schedule side-effects were not a limiting factor to its use. Aza treatment induced a reduction in anti-AchR-antibody level that was correlated with clinical improvement and greatly decreased the need for steroids.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Azathioprine / adverse effects
  • Azathioprine / therapeutic use*
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunosuppression Therapy
  • Male
  • Myasthenia Gravis / drug therapy*
  • Myasthenia Gravis / immunology
  • Steroids / adverse effects
  • Steroids / therapeutic use*


  • Steroids
  • Azathioprine