Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing

Chin J Integr Med. 2019 Jul;25(7):554-560. doi: 10.1007/s11655-018-3021-3. Epub 2019 Jan 9.


Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine (TMP), one of the most widely used medicinal compound isolated from traditional Chinese herb, is usually employed for anti-oxidation, anti-inflammation, anti-platelet aggregation, anti-lipid, anti-fibrosis, as well as activating blood, removing stasis, dilating small arteries, improving microcirculation and antagonizing calcium. In the present paper, the anti-adhesion effect of TMP were reviewed. TMP was found to play a multi-target and muti-link role in anti-adhesion by inhibiting hyperplasia of collagen and overexpression of adhesion-related factors and reducing the concentration of white blood cells and fibrin in plasma. Because previous studies mostly focused on in vitro experiments and animal experiments, there is an urgent need for clinical research with abundant indicators to further prove its anti-adhesion potency. Future basic research should concentrate on the development of TMP as a biological material.

Keywords: pharmacological activity; review; tetramethylpyrazine; tissue adhesion.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Drug Repositioning*
  • Humans
  • Postoperative Complications / drug therapy*
  • Pyrazines / therapeutic use*
  • Tissue Adhesions / drug therapy*


  • Pyrazines
  • tetramethylpyrazine