Monoclonal gammopathy of undetermined significance: A primary care guide

Cleve Clin J Med. 2019 Jan;86(1):39-46. doi: 10.3949/ccjm.86a.17133.


Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up. Patients with MGUS can be risk-stratified on the basis of the amount and type of their monoclonal protein as well as whether they have an abnormal light-chain ratio. Here, we provide a guide to the diagnosis, workup, and management of MGUS.

Publication types

  • Review

MeSH terms

  • Humans
  • Paraproteinemias / diagnosis
  • Paraproteinemias / therapy*