Myricetin inhibits panel of kinases implicated in tumorigenesis

Basic Clin Pharmacol Toxicol. 2019 Jul;125(1):3-7. doi: 10.1111/bcpt.13201. Epub 2019 Mar 12.


Myricetin is a flavonoid with several biological properties, including antioxidant and anti-inflammatory features. Its protective effect in chronic diseases may occur through the inhibition of protein kinases that trigger inflammation and carcinogenesis pathways. Considering the influence of kinases on such pathological disorders, it is crucial to study compounds that inhibit these proteins. This study aims to evaluate the inhibitory potential of 14 flavonoids on TNF-α release in human whole blood as well as the inhibitory potential of myricetin towards kinases involved in tumorigenesis. Our results showed that, out of all flavonoids, myricetin had the highest inhibitory effect on TNF-α level. In addition, myricetin showed potential as a multi-anti-kinase compound, reducing the activity of 7 kinases by >70% and of 9 kinases by >90%. Together these data demonstrate the great inhibitory activity of myricetin on tumorigenic kinases and potential for the development of new therapeutics.

Keywords: TNF-α; cancer; flavonoid; kinase; myricetin.

MeSH terms

  • Carcinogenesis / drug effects*
  • Drug Screening Assays, Antitumor
  • Flavonoids / pharmacology*
  • Humans
  • Inflammation / blood
  • Inflammation / drug therapy*
  • Inflammation / immunology
  • Neoplasms / blood
  • Neoplasms / drug therapy*
  • Protein Kinase Inhibitors / pharmacology*
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / immunology
  • Tumor Necrosis Factor-alpha / metabolism


  • Flavonoids
  • Protein Kinase Inhibitors
  • TNF protein, human
  • Tumor Necrosis Factor-alpha
  • myricetin