Serologic studies in patients with systemic lupus erythematosus and central nervous system dysfunction

Arthritis Rheum. 1978 Apr;21(3):289-94. doi: 10.1002/art.1780210301.


Serologic studies were performed on 25 patients with systemic lupus erythematosus (SLE) during 29 acute episodes of central nervous system (CNS) disease. Increased anti-DNA antibody and decreased total serum hemolytic complement activity were observed only in those patients with associated extra-CNS disease manifestations. Patients with isolated CNS disease were otherwise in apparent clinical and serological remission regarding these two indices. No special association of cold-reactive IgM antilymphocyte antibodies was demonstrable in patients with ongoing CNS injury. Of special interest was an increased incidence of anti-Sm antibodies in the patients with CNS dysfunction relative to that in a large group of patients without neuropsychiatric disease. The incidence of anti-RNP was not increased. The data do not support direct involvement in SLE brain injury of either DNA/anti-DNA complexes or of lymphocytotoxic antibodies cross-reactive with brain cells, but do suggest an association of anti-Sm with CNS disease in this disorder.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies / analysis
  • Antibodies, Antinuclear / analysis
  • Central Nervous System Diseases / complications
  • Central Nervous System Diseases / immunology*
  • Complement System Proteins / analysis
  • DNA / immunology
  • Humans
  • Immunoglobulin M / analysis
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / immunology*
  • Lymphocytes / immunology


  • Antibodies
  • Antibodies, Antinuclear
  • Immunoglobulin M
  • Complement System Proteins
  • DNA