Neodymium: YAG and argon laser iridotomy. Long-term follow-up in a prospective, randomized clinical trial

Ophthalmology. 1988 Sep;95(9):1207-11. doi: 10.1016/s0161-6420(88)33039-3.


Neodymium:YAG (Nd:YAG) and argon laser iridotomies were compared in a prospective, randomized clinical trial of 43 patients with bilateral chronic pupillary-block glaucoma. All patients had one eye randomly assigned to argon and the fellow eye assigned to Nd:YAG laser treatment. Follow-up ranged from 20 to 42 months. Iridotomy closure was not observed in Nd:YAG-treated eyes, but nine (21%) argon iridotomies required retreatment. Visual loss due to progression of laser-induced lens or corneal damage was not observed in any eye. Nine (21%) argon-treated eyes and eight (19%) Nd:YAG-treated eyes required laser trabeculoplasty for further intraocular pressure (IOP) lowering after iridotomy. Five (12%) argon-treated and two (5%) Nd:YAG-treated eyes required intraocular filtration surgery for long-term IOP control, but this difference was not statistically significant. There were no significant long-term differences between these treatment modalities.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Argon
  • Clinical Trials as Topic
  • Follow-Up Studies
  • Glaucoma / surgery*
  • Humans
  • Intraocular Pressure
  • Iris / surgery*
  • Laser Therapy / adverse effects
  • Laser Therapy / methods*
  • Middle Aged
  • Neodymium
  • Prospective Studies
  • Random Allocation


  • Neodymium
  • Argon