Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 10;8:e43777.
doi: 10.7554/eLife.43777.

How Bacteria Arrange Their Organelles

Affiliations
Free PMC article

How Bacteria Arrange Their Organelles

Emilia Mauriello. Elife. .
Free PMC article

Abstract

The structures responsible for photosynthesis in bacteria use the nucleoid and two unique proteins as a scaffold to position themselves.

Keywords: Synechococcus elongatus PCC 7942; carboxysomes; cyanobacteria; infectious disease; microbiology; protein self-organization.

Conflict of interest statement

EM No competing interests declared

Figures

Figure 1.
Figure 1.. The proteins McdA and McdB interact to position carboxysomes in bacterial cells.
Left: Synechococcus elongatus cells bearing one or multiple carboxysomes (green pentagons). McdB proteins on the surface of the carboxysomes create a gradient of McdA (pink) that oscillates across the surface of the nucleoid. Carboxysomes move to the highest concentration of McdA, but McdB causes McdA to dissociate more easily from the nucleoid surface. In cells containing one carboxysome (top), the carboxysome sits at the McdA-depleted region of the nucleoid. In cells containing two or more carboxysomes, the carboxysomes move apart from each other until they end up equally spaced across the nucleoid. Right: Schematic diagram of a carboxysome (adapted from http://2014.igem.org/Team:Bielefeld-CeBiTec/Project/CO2-fixation/Carboxysome; CC BY 3.0). Carboxysomes contain the key enzymes for photosynthesis – RuBisCO and carbonic anhydrase. McdB proteins (light green diamonds) on the surface of carboxysomes allow the carboxysomes to interact with McdA on the surface of nucleoids.

Comment on

  • eLife. doi: 10.7554/eLife.39723

Similar articles

See all similar articles

References

    1. Alvarado A, Kjær A, Yang W, Mann P, Briegel A, Waldor MK, Ringgaard S. Coupling chemosensory array formation and localization. eLife. 2017;6:e31058 doi: 10.7554/eLife.31058. - DOI - PMC - PubMed
    1. Henry JT, Crosson S. Chromosome replication and segregation govern the biogenesis and inheritance of inorganic polyphosphate granules. Molecular Biology of the Cell. 2013;24:3177–3186. doi: 10.1091/mbc.e13-04-0182. - DOI - PMC - PubMed
    1. Hu L, Vecchiarelli AG, Mizuuchi K, Neuman KC, Liu J. Brownian ratchet mechanisms of ParA-mediated partitioning. Plasmid. 2017;92:12–16. doi: 10.1016/j.plasmid.2017.05.002. - DOI - PMC - PubMed
    1. MacCready JS, Hakim P, Young EJ, Hu L, Liu J, Osteryoung KW, Vecchiarelli AG, Ducat DC. Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria. eLife. 2018;7:e39723 doi: 10.7554/eLife.39723. - DOI - PMC - PubMed
    1. Mauriello EMF, Jones C, Moine A, Armitage JP. Cellular targeting and segregation of bacterial chemosensory systems. FEMS Microbiology Reviews. 2018;42:462–476. doi: 10.1093/femsre/fuy015. - DOI - PubMed

Substances

Supplementary concepts

Feedback