Intracranial Hemorrhaging Following Cardiobacterium hominis Endocarditis

Intern Med. 2019 May 1;58(9):1361-1365. doi: 10.2169/internalmedicine.2111-18. Epub 2019 Jan 10.


Acute infectious endocarditis (IE) is a complex disease that presents as a serious clinical condition associated with a high mortality rate, especially due to intracranial hemorrhaging (ICH). The most common causative organism is Staphylococcus aureus. We herein report a patient with ICH following subacute IE with a positive blood culture for Cardiobacterium hominis. A review of the existing literature revealed that acute IE associated with Cardiobacterium has been reported to cause ICH in only seven previous cases. Prolonged culture-specific antibiotic therapy along with extended surveillance of blood culture is therefore essential for timely intervention.

Keywords: HACEK; blood culture; infectious endocarditis; stroke; valvular disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Cardiobacterium*
  • Endocarditis, Bacterial / complications*
  • Female
  • Gram-Negative Bacterial Infections / complications*
  • Humans
  • Intracranial Hemorrhages / microbiology*
  • Male
  • Middle Aged


  • Anti-Bacterial Agents