Solitary plasmacytoma of the skull, a single malignant monoclonal plasma cell proliferation without systemic involvement, is rare and often misdiagnosed by radiological examinations only. In this article, the authors presented a 40-year-old man who had a painless protruding mass over the midline of the posterior head region. A brain magnetic resonance imaging (MRI) revealed an enhanced mass lesion over the midline of the parieto-occipital region with skull erosion. Under the tentative diagnosis of meningioma, craniectomy was performed with en bloc tumor resection, and the skull defect was replaced by cranioplasty with bone cement. The final histopathological report revealed plasmacytoma without evidence of multiple myeloma. No further adjuvant radiotherapy was arranged for the patient. The postoperative course was uneventful within a one-year follow-up period. For the skull solitary plasmacytoma, there was no strong evidence that adjuvant radiotherapy was necessary after the primary surgery. Surgical intervention with total tumor resection is an effective option for the patient with solitary plasmacytoma of the skull.
Keywords: solitary plasmacytoma; solitary plasmacytoma of skull.