Non-infectious Granulomatous Lesions of the Orofacial Region

Head Neck Pathol. 2019 Sep;13(3):449-456. doi: 10.1007/s12105-018-00997-w. Epub 2019 Jan 9.


Granulomatous lesions of the orofacial region are a heterogeneous group of disorders characterized by a granulomatous reaction to a variety of stimuli. Infectious agents, foreign material, systemic inflammation and metabolic disorders can all be associated with granulomatous inflammation. In the orofacial region primary causes of granulomatosis include foreign body reaction, delayed hypersensitivity to topical agents and idiopathic orofacial granulomatosis. Secondary causes of granulomas include infectious agents, sarcoid, and Crohn disease. For this review, infectious causes of orofacial granulomatosis (OFG) including bacteria, parasites and fungi will not be discussed.

Keywords: Cheilitis granulomatosis; Crohn disease; Melkersson Rosenthal; Orofacial granulomatosis; Sarcoid.

Publication types

  • Review

MeSH terms

  • Granulomatosis, Orofacial / diagnosis*
  • Granulomatosis, Orofacial / etiology*
  • Granulomatosis, Orofacial / pathology*
  • Humans