Besides the steroids and the cytostatics used in the treatment of systemic connective tissue diseases, there are other drugs which could be also used in the treatment of these diseases. Of the so-called nonsteroidal anti-inflammatory and slow-acting antirheumatic drugs importance of the quinoline antimalarial drugs is pointed out. The action of the pyrazolone and indole derivatives is weaker. The action of some enzymic drugs in sclerodermia is pointed out as a novelty. The use of direct and indirect anticoagulants and of calcium antagonists is relatively limited but very important in the treatment of systemic vasculitis and lupus nephropathies.