Abstract
Syphilis and human immunodeficiency virus (HIV) infections are both transmitted sexually. Co-infection of HIV and syphilis alters the course of both diseases. Clinical presentation of syphilis in patients of HIV may be atypical. HIV-infected individuals are at risk of developing lues maligna, which is characterized by nodulo-ulcerative lesions associated with severe constitutional symptoms. Erythroderma secondary to generalized papulo-squamous lesions of secondary syphilis is also uncommon. Here we report two cases of atypical presentations of secondary syphilis in HIV-positive patients.
Keywords:
HIV; Nodulo-ulcerative syphilis; erythroderma; secondary syphilis.
MeSH terms
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AIDS-Related Opportunistic Infections / complications*
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AIDS-Related Opportunistic Infections / drug therapy
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Administration, Oral
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Adult
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / therapeutic use
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Chancre
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Coinfection / complications
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Fluconazole / administration & dosage
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Fluconazole / therapeutic use
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HIV Seropositivity / complications*
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Humans
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Injections, Intravenous
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Male
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Metronidazole / administration & dosage
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Metronidazole / therapeutic use
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Penicillins / administration & dosage
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Penicillins / therapeutic use
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Skin Ulcer / complications*
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Skin Ulcer / drug therapy
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Skin Ulcer / microbiology
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Syphilis / diagnosis*
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Syphilis / drug therapy
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Treatment Outcome
Substances
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Anti-Infective Agents
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Penicillins
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Metronidazole
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Fluconazole