Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Apr;44(4):874-883.
doi: 10.1007/s11064-019-02720-9. Epub 2019 Jan 10.

Morphine Dependence Is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats


Morphine Dependence Is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats

Sohyeon Moon et al. Neurochem Res. .


The effect of 3, 4, 5-trimethoxy cinnamic acid (TMCA) against morphine-induced dependence in mice and rats was investigated. Mice were pretreated with TMCA and then morphine was injected intraperitoneally; whereas rats were treated with TMCA (i.p.) and infused with morphine into the lateral ventricle of brain. Naloxone-induced morphine withdrawal syndrome and conditioned place preference test were performed. Moreover, western blotting and immunohistochemistry were used to measure protein expressions. Number of naloxone-precipitated jumps and conditioned place preference score in mice were attenuated by TMCA. Likewise, TMCA attenuated morphine dependent behavioral patterns such as diarrhea, grooming, penis licking, rearing, teeth chattering, and vocalization in rats. Moreover, the expression levels of pNR1and pERK in the frontal cortex of mice and cultured cortical neurons were diminished by TMCA. In the striatum, pERK expression was attenuated despite unaltered expression of pNR1 and NR1. Interestingly, morphine-induced elevations of FosB/ΔFosB+ cells were suppressed by TMCA (50, 100 mg/kg) in the nucleus accumbens sub-shell region of mice. In conclusion, TMCA could be considered as potential therapeutic agent against morphine-induced dependence.

Keywords: 3, 4, 5-Trimethoxy cinnamic acid (TMCA); FosB; Morphine dependence; NMDA; Nucleus accumbens.

Similar articles

See all similar articles


    1. Neuropsychopharmacology. 2001 Aug;25(2):204-12 - PubMed
    1. J Biol Chem. 2003 Apr 18;278(16):13919-27 - PubMed
    1. Eur J Pharmacol. 1992 May 14;215(2-3):333-6 - PubMed
    1. Ann N Y Acad Sci. 2003 Nov;1003:368-71 - PubMed
    1. Biol Pharm Bull. 2004 Aug;27(8):1317-9 - PubMed

LinkOut - more resources