Probing membrane asymmetry of ABC polymersomes

Evgeniia V Konishcheva; Davy Daubian; Serena Rigo; Wolfgang P Meier

doi:10.1039/c8cc09659g

Probing membrane asymmetry of ABC polymersomes

Chem Commun (Camb). 2019 Jan 25;55(8):1148-1151. doi: 10.1039/c8cc09659g. Epub 2019 Jan 11.

Authors

Evgeniia V Konishcheva¹, Davy Daubian², Serena Rigo², Wolfgang P Meier²

Affiliations

¹ Department of Physical Chemistry, University of Basel, Mattenstrasse 24a, BPR 1096, 4058 Basel, Switzerland. wolfgang.meier@unibas.ch and Precision Macromolecular Chemistry, Institute Charles Sadron, UPR-22 CNRS, BP 84047, 23 rue du Loess, 67034 Strasbourg Cedex 2, France. ev.konishcheva@gmail.com.
² Department of Physical Chemistry, University of Basel, Mattenstrasse 24a, BPR 1096, 4058 Basel, Switzerland. wolfgang.meier@unibas.ch.

PMID: 30632557
DOI: 10.1039/c8cc09659g

Abstract

We report the sensitivity of the membrane asymmetry of ABC (PEO-b-PCL-b-PMOXA) polymersomes towards the end-group modification of a shorter C block. While a non-modified ABC polymer formed polymersomes with the A block outside and the C block inside, a mixture of ABC and ABC-biotin formed polymersomes with the C block outside.

MeSH terms

Biotin / chemical synthesis
Biotin / chemistry
Catalysis
Copper / chemistry
Molecular Structure
Polyamines / chemical synthesis*
Polyamines / chemistry
Polyesters / chemical synthesis*
Polyesters / chemistry

Substances

Polyamines
Polyesters
poly(2-methyl-2-oxazoline)
polyethylene oxide-polycaprolactone copolymer
Biotin
Copper