Cold-field fruit extracts exert different antioxidant and antiproliferative activities in vitro

Zi-Luan Fan; Zhen-Yu Wang; Jia-Ren Liu

doi:10.1016/j.foodchem.2011.04.091

Cold-field fruit extracts exert different antioxidant and antiproliferative activities in vitro

Food Chem. 2011 Nov 15;129(2):402-407. doi: 10.1016/j.foodchem.2011.04.091. Epub 2011 May 4.

Authors

Zi-Luan Fan¹, Zhen-Yu Wang², Jia-Ren Liu³

Affiliations

¹ Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, PR China. Electronic address: fzl_1122@163.com.
² Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, PR China; Northeast Forestry University, 26 Hexing Road, Xiangfang District, Harbin 150040, PR China. Electronic address: wzy219001@yahoo.com.cn.
³ Harvard Medical School, 300 Longwood Ave., Boston, MA 02115-5737, USA. Electronic address: Jia-ren.liu@childrens.harvard.edu.

PMID: 30634244
DOI: 10.1016/j.foodchem.2011.04.091

Abstract

Consumption of plant phenolics in the daily diet has been recognised as lowering the risk of aging-associated diseases. A total of 11 cold-field fruits in China were evaluated for total contents of phenolics, flavonoids and anthocyanins, and antioxidant and antiproliferation activities. Total phenolic contents of the fruits extracts had a positive correlation with antioxidant activity (R²>0.7112). Among the 11 fruits, the extracts of raspberry had the highest capacities for scavenging DPPH (EC₅₀ 25.6±0.51μM TE/g FW) and ABTS⁺ (EC₅₀ 63.6±1.67μM TE/g FW). Proliferation of HepG2 and HT-29 cells was significantly inhibited in a dose-dependent pattern after exposure to the fruit extracts, among which lingonberry and rowanberry exhibited the highest antiproliferative activities. These results provide new knowledge on health functions of fruits and the fruits with high antioxidant contents are recommended for potential health benefits.

Keywords: Antioxidant activity; Antiproliferative activity; Cancer; Cold-field fruits; Extraction; Phenolics.