Purpose: Three compounds obtained from ephedrine were identified and characterized by various instrumental analytical methods. Ephedrone (methcathinone) hydrochloride and its fundamental derivatives N-acetylephedrine and N-acetylephedrone were analyzed as precursors of a cathinone derivative.
Methods: The obtained samples were analyzed by gas chromatography coupled with mass spectrometry, nuclear magnetic resonance spectroscopy, infrared and Raman spectroscopy, and X-ray crystallography.
Results: The three compounds were confirmed as: N-methyl-2-amino-1-phenylpropan-1-one (methcathinone) hydrochloride, N-acetyl-N-methyl-2-amino-1-phenylpropan-1-one (cathinone derivative), and N-acetyl-N-methyl-2-amino-1-phenylpropan-1-ol (acetyl derivative of ephedrine).
Conclusions: X-ray crystallography is especially useful for identifying the new designer drugs and their different precursor forms.
Keywords: Ephedrine as synthesis precursor; Infrared spectroscopy; Methcathinone (ephedrone); NMR spectroscopy; Raman spectroscopy; X-ray crystallography.
Conflict of interest statement
The authors have no financial or other relations that could lead to a conflict of interest.This article does not contain any studies with human participants or animals performed by any of the authors.
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