Modular Lattice Constructs for Biological Joint Resurfacing

Tissue Eng Part A. 2019 Jul;25(13-14):1053-1062. doi: 10.1089/ten.TEA.2018.0231. Epub 2019 Mar 18.


The repair of large articular cartilage lesions is still a major challenge. In particular, the fixation of the grafts to the subchondral bone plate represents an unresolved problem. In this work, we present a completely novel concept based on a modular lattice, combining building blocks of different ceramic materials, anchoring pins and space for cell-loaded hydrogels or other scaffold materials. This concept targets not only circumscribed cartilage defects but also large osteoarthritic lesions. It spans the bridge between cell therapy and artificial joint arthroplasty, and thus is of significant medical and socioeconomic impact.

Keywords: 3D cell culture; cartilage; cell adhesion; extracellular matrix; modular scaffold.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bone and Bones / diagnostic imaging
  • Bone and Bones / drug effects
  • Cell Adhesion / drug effects
  • Cell Communication / drug effects
  • Cell Differentiation / drug effects
  • Ceramics / pharmacology
  • Collagen / pharmacology
  • Humans
  • Hydrogels / pharmacology
  • Implants, Experimental
  • Joints / physiology*
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / drug effects
  • Middle Aged
  • Tensile Strength
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry*
  • X-Ray Microtomography


  • Hydrogels
  • Collagen