Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions

Bioorg Med Chem Lett. 2019 Feb 15;29(4):619-622. doi: 10.1016/j.bmcl.2018.12.048. Epub 2018 Dec 22.


Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

Keywords: 8-MOP; 8-Methoxypsoralen; Dark-reaction toxicity; Keratinocytes; PAM212; Phototoxicity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Survival / drug effects*
  • Cells, Cultured
  • Darkness*
  • Humans
  • Keratinocytes / drug effects
  • Keratinocytes / radiation effects
  • Light*
  • Methoxsalen / chemistry
  • Methoxsalen / pharmacology*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Skin Diseases / pathology


  • Photosensitizing Agents
  • Methoxsalen