Miscarriage chromosome testing: Indications, benefits and methodologies

Dana B McQueen; Ruth B Lathi

doi:10.1053/j.semperi.2018.12.007

Miscarriage chromosome testing: Indications, benefits and methodologies

Semin Perinatol. 2019 Mar;43(2):101-104. doi: 10.1053/j.semperi.2018.12.007. Epub 2018 Dec 20.

Authors

Dana B McQueen¹, Ruth B Lathi²

Affiliations

¹ Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University, Chicago, IL, United States. Electronic address: dana.mcqueen@northwestern.edu.
² Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University, Chicago, IL, United States; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University, Palo Alto, United States.

PMID: 30638881
DOI: 10.1053/j.semperi.2018.12.007

Abstract

Rapid advances in genomics have expanded the use of chromosome testing following miscarriage. In addition to conventional cytogenetics, the availability of single nucleotide polymorphism microarray technology and array comparative geneomic hybridization have provided further options for clinicians. This review will cover the indications for testing and the advantages/disadvantages of the various methodologies available.

Keywords: Aneuploidy; Genetics; Miscarriage; Recurrent Pregnancy Loss.

Publication types

Review

MeSH terms

Abortion, Habitual / genetics*
Abortion, Spontaneous / genetics*
Chromosome Disorders / genetics*
Female
Genetic Predisposition to Disease
Genetic Testing*
Humans
Karyotyping*
Polymorphism, Single Nucleotide / genetics*
Pregnancy
Prenatal Diagnosis