Neuropathic diabetic foot ulcers treated with cerium dioxide nanoparticles: A case report

Diabetes Metab Syndr. 2019 Jan-Feb;13(1):228-234. doi: 10.1016/j.dsx.2018.08.027. Epub 2018 Aug 29.


Wound healing in diabetes is frequently impaired and its treatment remains a challenge. The ability of topical application of cerium (Ce) dioxide nanoparticles (CNPs) to accelerate wound healing in an animal model provides a rationale to develop this technology for use in humans affected by traumatic injury, diabetes and burns. We first described a case report of successful topical treatment of neuropathic diabetic foot ulcers with novel gel containing CNPs. The CNPs has bacteriostatic activity, anti-inflammatory properties and can penetrated into the wound tissue and reduced oxidative damage therefore protect regenerative tissue, suggesting a therapeutic potential for topical treatment of diabetic foot ulcers.

Keywords: Cerium dioxide nanoparticles; Diabetic foot; Neuropathic ulcers; Pressure ulcers.

Publication types

  • Case Reports

MeSH terms

  • Cerium / administration & dosage*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Foot / drug therapy*
  • Diabetic Foot / etiology
  • Humans
  • Male
  • Middle Aged
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Prognosis
  • Wound Healing


  • Cerium
  • ceric oxide