Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review

Int J Mol Sci. 2019 Jan 11;20(2):277. doi: 10.3390/ijms20020277.


Background: The aims of this narrative review were to examine up-to-date literature in order to evaluate the effectiveness of arthrocentesis or injections with platelet-rich plasma in temporomandibular affections and to compare them to arthrocentesis alone or with hyaluronic acid (HA) or to hyaluronic acid injections.

Methods: The search of international literature was made on the PMC, PubMed and Cochrane databases, including all full-length text of studies on humans focused on osteoarthritis and disc displacements and their treatment with platelet-rich plasma arthrocentesis or injections. All design studies were included in the review and they were examined for three different outcomes: pain, joint sound and mandibular motion. English papers were only selected.

Results: Even though the low number of studies in this field, arthrocentesis with platelet-rich plasma and platelet-rich plasma injections in temporomandibular disorders' management were found to be effective in reducing pain and joint sound as well as in improving mandibular motion in a maximum follow-up of 24 months.

Conclusion: Comparison to arthrocentesis alone or to HA use in arthrocentesis or by injections provided encouraging results in terms of the effectiveness of platelet-rich plasma use.

Keywords: arthrocentesis; hyaluronic acid; injection; platelet-rich plasma; temporomandibular joint (TMJ); temporomandibular joint disorders (TMD).

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Arthrocentesis / methods*
  • Humans
  • Hyaluronic Acid / administration & dosage
  • Hyaluronic Acid / physiology
  • Injections
  • Pain Measurement
  • Platelet-Rich Plasma / physiology*
  • Range of Motion, Articular / drug effects
  • Temporomandibular Joint Dysfunction Syndrome / physiopathology
  • Temporomandibular Joint Dysfunction Syndrome / therapy*
  • Treatment Outcome


  • Hyaluronic Acid