Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 5;30(1):30-36.
doi: 10.2188/jea.JE20180119. Epub 2019 Jan 12.

Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection

Affiliations
Free PMC article

Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection

Masumi Okuda et al. J Epidemiol. .
Free PMC article

Abstract

Background: Distributions of serum pepsinogen (PG) values were assessed in Helicobacter pylori-infected and non-infected junior high school students (aged 12-15 years) in Japan.

Methods: All junior high school students (1,225 in total) in Sasayama city, who were basically healthy, were asked to provide urine and serum samples, which were used to measure urine and serum H. pylori antibodies using ELISA kits and PG values. The subjects, whose urine and serum antibodies were both positive, were considered H. pylori infected.

Results: Of the 187 subjects who provided urine and blood samples, 8 were infected, 4 had discrepant results, 4 had negative serum antibody titers no less than 3.0 U/ml, and 171 were non-infected. In the H. pylori non-infected subjects, the median PG I and PG II values and PG I to PG II ratio (PG I/II) were 40.8 ng/mL, 9.5 ng/mL, and 4.4, respectively, whereas in the infected subjects, these values were 55.4 ng/mL, 17.0 ng/mL, and 3.3, respectively (each P < 0.01). In the non-infected subjects, PG I and PG II were significantly higher in males than in females (P < 0.01).

Conclusions: The PG I and PG II values were higher, and the PG I/II was lower in H. pylori infected students than in non-infected students. In H. pylori non-infected students, males showed higher PG I and PG II values than females. The distributions of PG values in junior high school students differed from those in adults.

Keywords: serum antibody; serum pepsinogen; students; urine antibody.

Figures

Figure 1.
Figure 1.. A flow chart for the selection of study subjects
Figure 2.
Figure 2.. Comparison of PG values between H. pylori infected and non-infected subjects
Figure 3.
Figure 3.. Comparison of PG values between males and females in H. pylori non-infected subjects
Figure 4.
Figure 4.. ROC (receiver operating characteristics) curves of PG II and PG I/PG II for H. pylori infection. The optimal criterion using both PG II and PG I/PG II is shown as closed circle (for more details see text).

Similar articles

See all similar articles

References

    1. Samloff IM. Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence. Gastroenterology. 1971;61:185–188. - PubMed
    1. Rotter JI, Wong FL, Samloff IM, et al. Evidence for a major dominance component in the variation of serum pepsinogen I levels. Am J Hum Genet. 1982;34:395–401. - PMC - PubMed
    1. Miki K, Ichinose M, Shimizu A, et al. Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterol Jpn. 1987;22:133–141. 10.1007/BF02774209 - DOI - PubMed
    1. Kikuchi S, Kurosawa M, Sakiyama T, et al. Long-term effect of Helicobacter pylori infection on serum pepsinogens. Jpn J Cancer Res. 2000;91:471–476. 10.1111/j.1349-7006.2000.tb00969.x - DOI - PMC - PubMed
    1. Furuta T, Kaneko E, Baba S, Arai H, Futami H. Percentage changes in serum pepsinogens are useful as indices of eradication of Helicobacter pylori. Am J Gastroenterol. 1997;92:84–88. - PubMed
Feedback