The frequency of the polymorphism rs11801197 of calcitonin receptor gene (CALCR) was studied by real-time PCR in 422 Moscow women and children, including pregnant women (n=96), lactating (n=29) and non-pregnant women (n=28) and children (n=269) of preschool (2-6 years, n=76) and school age (7-16 years, n=193) with different levels of bone strength (BS) as determined by ultrasound densitometry. It was found that the decrease in the value of the BS (Z-score<-1) was observed in 60% of women, 54% of preschool children and 48% of school children. In the cohort studied the predominant genotype of rs11801197 polymorphism of CALCR gene was CT (38%), the frequency of the genotypes CC and TT - 31%, C and T allele - 50%. There was statistically significant association of BS reduction risk with a C allele of rs11801197 polymorphism of CALCR gene in all examined women (QR=2.034, p=0.02). A positive but not statistically significant association of BS reduction risk with C allele of polymorphism in non-pregnant and pregnant women was found (OR=6.905, p=0.09 and OR=1.902, p=0.09 respectively). The same tendency was observed in preschool children (OR=1.880, p=0.104). In school-aged children C allele was not associated with the risk of BS reduction (OR=0.866, p=0.595). Thus, the allele C is the risk allele of BS reduction. The frequency of CC genotype in Moscow women is much higher than that in women in Europe and in women of North-West region of Russian Federation. Women in the Moscow region - the carriers of rs11801197 polymorphism of CALR - gene need in personalized support of their bone health.
Keywords: calcitonin receptor gene (CALCR); genetic polymorphism; osteoporosis; pregnant and lactating women; preschoolers; school-aged children; women.
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