The Deadly Bite of STAT3

Hagen Schwenzer; Ariberto Fassati

doi:10.1016/j.ccell.2018.12.004

The Deadly Bite of STAT3

Cancer Cell. 2019 Jan 14;35(1):5-7. doi: 10.1016/j.ccell.2018.12.004.

Authors

Hagen Schwenzer¹, Ariberto Fassati²

Affiliations

¹ Department of Oncology, Oxford University, Oxford OX3 7DQ, UK.
² Division of Infection and Immunity, University College London, London WC1E 4JF, UK. Electronic address: a.fassati@ucl.ac.uk.

PMID: 30645976
DOI: 10.1016/j.ccell.2018.12.004

Abstract

The Tasmanian devils' facial tumor disease (DFTD) is a transmissible cancer that spreads by biting and threatens extinction of this marsupial. In this issue of Cancer Cell, Kosack et al. describe how overexpression of ERBB and uncontrolled activation of STAT3 drive DFTD growth and immune evasion.

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MeSH terms

Animals
Facial Neoplasms*
Marsupialia*